Endocrine Abstracts

Background: The relationships between thyroid hormones (TH) and platelets (PLT) have not been fully established. Physiological concentrations of L-thyroxine (T4) activate human PLT resulting in ATP release and aggregation. On the other hand, subclinical hypothyroidism has been frequently associated with hypercoagulability, in particular mean platelet volume (MPV), a marker of platelet activation, has been found higher in patients with subclinical hypothyroidism. A possible pro...

Background: Metabolic syndrome (MS) is associated with increased mortality, and the key factors predictive of its development among patients with obesity are still unclear. We recently demonstrated with a machine learning approach that Insulin-like Growth Factor 1 (IGF-1) is a novel marker of metabolic health and that in individuals with obesity, lower IGF-1 levels are associated with increased metabolic deterioration. However, the interpretation of IGF-1 serum measurement is ...

Background: Oxytocin (OXT) enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle.Dysfunction of the OXT system could underlie the pathogenesis of weight gain. Men and women with obesity were reported to have higher OXT blood levels compared to normal weight subjects. In contrast, metabolic syndrome has been associated with reduced fasting serum oxytocin in larger scale mixed gender studies.Aim: Data regarding the oxytocin sy...

Background: Reduced growth hormone (GH) secretory capacity is common in patients with obesity and metabolic derangements. The prevalence of GH deficiency (GHD) in this population is difficult to establish. Magnetic Resonance Imaging (MRI) pituitary findings may reflect specific endocrine alterations, as for GHD which is associated with lower pituitary height and volume (PV).Purpose: Our aim was to identify the pituitary morphological alterations predicti...